Investigation of Electronic Structure of Biogenic Amines by Photoelectron Spectroscopy: Histamine

B. Ruščić and L. Klasinc

Rugjer Bošković Institute, Zagreb, Croatia

Kem. Ind. (Zagreb) 27(11), 551-557 (1978)

The He(I) photoelectron spectrum of histamine was recorded and used to solve its electron configuration by examining the change in ionization energies along the series: imidazole, 4(5)-methylimidazole, and histamine, as well as benzene, toluene, ethylbenzene, phenethylamine, with particular focus on π-ionizations and ionizations from free electron pairs, which are believed to be important for the biological activity. The physiological and chemical characteristics of histamine and histamine antagonists are also reviewed and discussed.
Original written in Croatian.
For the work described in this paper, the lead author has received the traditional "Krka" Award in 1978 (an annual award for outstanding research by young scientists, sponsored by the pharmaceutical company "Krka", Novo Mesto, Slovenia)